Prior vinca alkaloids Active gastrointestinal disease or disorder Pregnant or lactating Serious co-morbid medical or psychological condition Prior bone marrow or stem cell transplant Prior documented severe sensitivity to 5-FU. Taken twice a day on days until disease progression or unacceptable side effects occur. Actual Primary Completion Date:. This article will review the encouraging results of single agent and combination therapy trials, compare vinorelbine activity to established therapies for breast cancer, consider novel routes of administration, and discuss ongoing randomized clinical trials and future studies that may lead to the widespread use of vinorelbine for the treatment of breast cancer. Vinorelbine Injection, USP is a cytotoxic drug. February Keywords provided by Craig A. The following adverse reactions have been identified during post-approval use of Vinorelbine. By clicking Subscribe, I agree to the Drugs.
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Vinorelbine- chemo treatment for metastatic breast cancer.
National Institutes of Health U. Two metabolites of Vinorelbine have been identified in human blood, plasma, and urine; Vinorelbine N-oxide and deacetylVinorelbine. Drugs Approved for Conditions Related to Cancer. If a drug has been approved for one use, physicians sometimes elect to use this same drug for other problems if they believe it might be helpful. MedlinePlus Information on Vinorelbine Tartrate - A lay language summary of important information about this drug that may include the following:. Department of Health and Human Services. Vinorelbine Injection, USP is available in single-use, clear glass vials with elastomeric stoppers and green caps, individually packaged in a carton in the following vial sizes:. Parenteral drug products should be visually inspected for particulate matter and discoloration prior to administration whenever solution and container permit. Vinorelbine is highly lipophilic, which results in more significant tissue uptake and a greater therapeutic index than the other vinca alkaloids.
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Current Status of Vinorelbine For Breast Cancer
Repeat neutrophil count in one week. Did it shrink the tumours and has it helped anyone to remission? There is no known antidote for overdoses of Vinorelbine. Diet and digestion have more to do with cancer prevention than you may realize. Research has demonstrated large variation between patients in the pharmacokinetics of vinorelbine, but the reasons for this diversity are unknown. In contrast to its significant myelosuppression, vinorelbine is associated with only modest nonhematologic toxicity. The podophyllotoxins are derived from the May apple plant. This includes vitamins, herbal supplements and over the counter remedies. Statistical Tools and Data. Vinorelbine is only mildly emetogenic, and coadministration of potent serotonin antagonist antiemetics is not routinely required.
Description:Proc Am Soc Clin Oncol Breast cancer is not an inevitability. It was not mutagenic in the Ames test and gave inconclusive results in the mouse lymphoma TK Locus assay. Hide glossary Glossary Study record managers: It is important not to become pregnant or father a child while you are having treatment with this drug and for at least 3 months afterwards. If you think you may have a medical emergency, call your physician or immediately. Oncology Journal , Breast Cancer.